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KMID : 0617320020110010217
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Journal of Pharmacetical Sceiences Ewha Womans University
2002 Volume.11 No. 1 p.217 ~ p.223
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Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells
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Hong, Chae Hee
Hur, Sun Kyung/Oh, O-Jin/Kim, Sun Sook/Nam, Kyung Ae/Lee, Sang Kook
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Abstract
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The inhibitors of prostaglandin biosynthesis and nitric oxide production have been considered as potential anti-inflammatory andcancer chernopreventive agents. In this study, we evaiuated approximately 170 methanol extracts of natural products includingKorean herbal medicines for the inhibition of prostaglandin E_2 production (for COX-2 inhioitors) and nitric oxide fumlation (feriNOS inhibitors) in lipopolysaccharide (LPS)-induced mouse macrophages RAW264.7 cells. As a result. several extracts such asAristolochia debilis, Cinnamomum cassia, Cinnamomum loureirii, Curcuma zedoaria, Eugenia caryophyllata, Pterocarpus santalius,Rehmania glutinosa and Tribulurs terrestris showed potent inhibition of COX-2 activity ( > 80% inhibition at the test concentrationof 10 μg/ml). In addition, the extracts of A. debilis, Caesalpinia sappan, Curcuma longa, C. zedoaria, Daphne genkwa and Morusalba were also considered as potential inhibitors of iNOS activity ( > 70% inhibition at the test concentration of 10 μg/ml). Theseactive extracts mediating COX-2 and iNOS inhibitory activities are warranted for further elucidation of active principles fordevelopment of new cancer chernopreventive and/or anti-inflammatory agents.
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